KIIIA [R10A] (P04308) Protein Card

General Information
Name KIIIA [R10A]
Organism synthetic construct
Protein Type Synthetic
Parent KIIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
CCNCSSKWCADHSRCC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1799.02
Monoisotopic Mass 1797.57
Isoelectric Point 10.92
Extinction Coefficient [280nm] 5500.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.2R. norvegicus158nM+/-30McArthur,J.R. et al. (2011)
Nav1.4R. norvegicus1.0uMMcArthur,J.R. et al. (2011)
Nav1.7R. norvegicus1.4uMMcArthur,J.R. et al. (2011)

References
McArthur,J.R., Singh,G., McMaster,D., Winkfein,R., Tieleman,D.P. and French,R.J. (2011) Interactions of key charged residues contributing to selective block of neuronal sodium channels by μ-conotoxin KIIIA. Mol. Pharmacol. 80:573-584

Internal links
Nucleic acids
Structure

External links

Tools