PIA [R1L] (P04315) Protein Card

General Information
Name PIA [R1L]
Organism synthetic construct
Protein Type Synthetic
Parent PIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
LDPCCSNPVCTVHNPQIC(nh2)
Modified residues
positionsymbolname
19nh2C-term amidation
Average Mass 1938.23
Monoisotopic Mass 1936.81
Isoelectric Point 5.63
Extinction Coefficient [280nm] NA

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
a7*α6β2*R. norvegicus3.2uM0.1nM epibatidinePucci,L. et al. (2011)

References
Pucci,L., Grazioso,G., Dallanoce,C., Rizzi,L., De Micheli,C., Clementi,F., Bertrand,S., Bertrand,D., Longhi,R., De Amici,M. and Gotti,C. (2011) Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors. FASEB J. 25:3775-3789

Internal links
Nucleic acids
Structure

External links

Tools