RDP-MII [R1ADMA] (P04318) Protein Card

General Information
Name RDP-MII [R1ADMA]
Organism synthetic construct
Protein Type Synthetic
Parent MII

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
(ADMA)DPGCCSNPVCHLEHSNLC(nh2)
Modified residues
positionsymbolname
1ADMAAsymmetric dimethylarginine
20nh2C-term amidation
Average Mass 2107.38
Monoisotopic Mass 2105.86
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
a7*α6β2*R. norvegicus(Low affinity site)14.7uM0.1nM epibatidinePucci,L. et al. (2011)
(High affinity site)4.5nM0.1nM epibatidinePucci,L. et al. (2011)

References
Pucci,L., Grazioso,G., Dallanoce,C., Rizzi,L., De Micheli,C., Clementi,F., Bertrand,S., Bertrand,D., Longhi,R., De Amici,M. and Gotti,C. (2011) Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors. FASEB J. 25:3775-3789

Internal links
Nucleic acids
Structure

External links

Tools