KIIIA [W8R] (P04321) Protein Card

General Information
Name KIIIA [W8R]
Organism synthetic construct
Protein Type Synthetic
Parent KIIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
CCNCSSKRCRDHSRCC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1854.11
Monoisotopic Mass 1852.66
Isoelectric Point 12.26
Extinction Coefficient [280nm] NA

Activity

IC50: Voltage-Gated Sodium Channels

TargetOrganismIC50nhillRef
Nav1.2R. norvegicus173nM+/-170.74Van Der Haegen,A. and Peigneur,S. and Tytgat,J. (2011)
Nav1.4R. norvegicus1.8uM+/-0.20.64Van Der Haegen,A. and Peigneur,S. and Tytgat,J. (2011)
Nav1.5H. sapiens>10uMVan Der Haegen,A. and Peigneur,S. and Tytgat,J. (2011)
Nav1.6M. musculus477nM+/-211.27Van Der Haegen,A. and Peigneur,S. and Tytgat,J. (2011)
Nav1.8H. sapiens>10uMVan Der Haegen,A. and Peigneur,S. and Tytgat,J. (2011)

References
Van Der Haegen,A., Peigneur,S. and Tytgat,J. (2011) Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. FEBS J. 278:3408-3418

Internal links
Nucleic acids
Structure

External links

Tools