KIIIA [W8Q] (P04322) Protein Card

General Information
Name KIIIA [W8Q]
Organism synthetic construct
Protein Type Synthetic
Parent KIIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
CCNCSSKQCRDHSRCC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1826.05
Monoisotopic Mass 1824.61
Isoelectric Point 11.73
Extinction Coefficient [280nm] NA

Activity

IC50: Voltage-Gated Sodium Channels

TargetOrganismIC50nhillRef
Nav1.2R. norvegicus332nM+/-310.97Van Der Haegen,A. and Peigneur,S. and Tytgat,J. (2011)
Nav1.4R. norvegicus3.5uM+/-0.20.98Van Der Haegen,A. and Peigneur,S. and Tytgat,J. (2011)
Nav1.5H. sapiens>10uMVan Der Haegen,A. and Peigneur,S. and Tytgat,J. (2011)
Nav1.6M. musculus910nM+/-411.16Van Der Haegen,A. and Peigneur,S. and Tytgat,J. (2011)
Nav1.8H. sapiens>10uMVan Der Haegen,A. and Peigneur,S. and Tytgat,J. (2011)

References
Van Der Haegen,A., Peigneur,S. and Tytgat,J. (2011) Importance of position 8 in μ-conotoxin KIIIA for voltage-gated sodium channel selectivity. FEBS J. 278:3408-3418

Internal links
Nucleic acids
Structure

External links

Tools