CVID[K10R] (P04324) Protein Card

General Information
Name CVID[K10R]
Organism synthetic construct
Protein Type Synthetic
Parent CVID

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family omega conotoxin

Sequence
CKSKGAKCSRLMYDCCSGSCSGTVGRC(nh2)
Modified residues
positionsymbolname
28nh2C-term amidation
Average Mass 2784.23
Monoisotopic Mass 2782.13
Isoelectric Point 11.95
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Calcium Channels

TargetOrganismIC50AgonistRef
Cav2.2R. norvegicus57pMGVIAMould,J. et al. (2004)

References
Mould,J., Yasuda,T., Schroeder,C.I., Beedle,A.M., Doering,C.J., Zamponi,G.W., Adams,D.J. and Lewis,R.J. (2004) The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J. Biol. Chem. 279:34705-34714
Schroeder,C.I., Adams,D., Thomas,L., Alewood,P.F. and Lewis,R.J. (2012) N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers 98:161-165

Internal links
Nucleic acids
Structure

External links

Tools