Ac-L1 (P04343) Protein Card

General Information
Name Ac-L1
Organism synthetic construct
Protein Type Synthetic
Parent RIIIK

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family kappa conotoxin

Sequence
(Ac)LOSCCSLNLRLCOVOACKRNOCCT(nh2)
Modified residues
positionsymbolname
1AcN-Acetate (on N-terminus)
3O4-Hydroxyproline
14O4-Hydroxyproline
16O4-Hydroxyproline
22O4-Hydroxyproline
26nh2C-term amidation
Average Mass 2691.17
Monoisotopic Mass 2689.17
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

IC50: Voltage-Gated Potassium Channels

TargetOrganismIC50Ref
Kv1.2O. mykiss7.6uM+/-0.8Al-Sabi,A. et al. (2004)

References
Al-Sabi,A., Lennartz,D., Ferber,M., Gulyas,J., Rivier,J.E., Olivera,B.M., Carlomagno,T. and Terlau,H. (2004) KappaM-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist. Biochemistry 43:8625-8635

Internal links
Nucleic acids
Structure

External links

Tools