RIIIK [L1H] (P04345) Protein Card

General Information
Name RIIIK [L1H]
Organism synthetic construct
Protein Type Synthetic
Parent RIIIK

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family kappa conotoxin

Sequence
HOSCCSLNLRLCOVOACKRNOCCT(nh2)
Modified residues
positionsymbolname
2O4-Hydroxyproline
13O4-Hydroxyproline
15O4-Hydroxyproline
21O4-Hydroxyproline
25nh2C-term amidation
Average Mass 2673.12
Monoisotopic Mass 2671.14
Isoelectric Point 12.52
Extinction Coefficient [280nm] NA

Activity

IC50: Voltage-Gated Potassium Channels

TargetOrganismIC50Ref
Kv1.2O. mykiss5.4uM+/-0.8Al-Sabi,A. et al. (2004)

References
Al-Sabi,A., Lennartz,D., Ferber,M., Gulyas,J., Rivier,J.E., Olivera,B.M., Carlomagno,T. and Terlau,H. (2004) KappaM-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist. Biochemistry 43:8625-8635

Internal links
Nucleic acids
Structure

External links

Tools