RgIA [R7K] (P04374) Protein Card

General Information
Name RgIA [R7K]
Organism synthetic construct
Protein Type Synthetic
Parent RgIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin
alpha conotoxin

Sequence
GCCSDPKCRYRCR
Average Mass 1542.78
Monoisotopic Mass 1541.61
Isoelectric Point 12.24
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α7R. norvegicus47.0uM1.1200uM AchEllison,M. et al. (2008)
α9α10R. norvegicus12.9uM1.350uM AchEllison,M. et al. (2008)

References
Ellison,M., Feng,Z.P., Park,A.J., Zhang,X., Olivera,B.M., McIntosh,J.M. and Norton,R.S. (2008) Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues. J. Mol. Biol. 377:1216-1227

Internal links
Nucleic acids
Structure

External links

Tools