PnIB [sTy15Y] (P04378) Protein Card

General Information
Name PnIB [sTy15Y]
Alternative name(s) PnIB
Organism synthetic construct
Protein Type Synthetic
Parent PnIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSLPPCALSNPDYC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1637.87
Monoisotopic Mass 1636.61
Isoelectric Point 5.47
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus1.97uM0.53300uM AchLuo,S. et al. (1999)
α7R. norvegicus61.3nM1.41mM AchLuo,S. et al. (1999)

Kd: Nicotinic acetylcholine receptors

TargetOrganismKdRef
α7R. norvegicus84.9nMLuo,S. et al. (1999)

References
Luo,S., Nguyen,T.A., Cartier,G.E., Olivera,B.M., Yoshikami,D. and McIntosh,J.M. (1999) Single-residue alteration in alpha-conotoxin PnIA switches its nAChR subtype selectivity Biochemistry 38:14542-14548

Internal links
Nucleic acids
Structure

External links

Tools