MII [L10A,L15A] (P04391) Protein Card

General Information
Name MII [L10A,L15A]
Organism synthetic construct
Protein Type Synthetic
Parent MII

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSNPVCHAEHSNAC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1626.77
Monoisotopic Mass 1625.56
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus17.2nM100uM acetylcholinMcIntosh,J.M. et al. (2004)
α6/α3β2β3R. norvegicus1.80nM100uM acetylcholinMcIntosh,J.M. et al. (2004)

References
McIntosh,J.M., Azam,L., Staheli,S., Dowell,C., Lindstrom,J.M., Kuryatov,A., Garrett,J.E., Marks,M.J. and Whiteaker,P. (2004) Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors. Mol. Pharmacol. 65:944-952

Internal links
Nucleic acids
Structure

External links

Tools