AnIB [non amidated] (P04395) Protein Card

General Information
Name AnIB [non amidated]
Organism synthetic construct
Protein Type Synthetic
Parent AnIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GGCCSHPACAANNQD(sTy)C
Modified residues
positionsymbolname
16sTySulfotyrosine
Average Mass 1788.86
Monoisotopic Mass 1787.50
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus540pM1.07100uM AchLoughnan,M.L. et al. (2004)
α7R. norvegicus367nM1.26100uM nicotineLoughnan,M.L. et al. (2004)

References
Loughnan,M.L., Nicke,A., Jones,A., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2004) Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone J. Med. Chem. 47:1234-1241

Internal links
Nucleic acids
Structure

External links

Tools