GI [R9A] (P04398) Protein Card

General Information
Name GI [R9A]
Organism synthetic construct
Protein Type Synthetic
Parent GI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ECCNPACGAHYSC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1352.48
Monoisotopic Mass 1351.42
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδM. musculus(site 1)60nM+/-13 10nM [125I]-BgtxGroebe,D.R. et al. (1997)
(site 2)>1mM10nM [125I]-BgtxGroebe,D.R. et al. (1997)
T. marmorata2.2uM+/-0.310nM [125I]-BgtxGroebe,D.R. et al. (1997)

References
Groebe,D.R., Gray,W.R., and Abramson,S.N. (1997) Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors Biochemistry 36:6469-6474

Internal links
Nucleic acids
Structure

External links

Tools