SI [P9K] (P04399) Protein Card

General Information
Name SI [P9K]
Organism synthetic construct
Protein Type Synthetic
Parent SI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ICCNPACGKKYSC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1384.66
Monoisotopic Mass 1383.55
Isoelectric Point 10.43
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδM. musculus(site 2)70uM+/-1.2 10nM [125I]-BgtxGroebe,D.R. et al. (1997)
(site 1)1.5nM+/-0.610nM [125I]-BgtxGroebe,D.R. et al. (1997)
T. marmorata(site 2)97nM+/-710nM [125I]-BgtxGroebe,D.R. et al. (1997)
(site 1)880pM+/-4010nM [125I]-BgtxGroebe,D.R. et al. (1997)

References
Groebe,D.R., Gray,W.R., and Abramson,S.N. (1997) Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors Biochemistry 36:6469-6474

Internal links
Nucleic acids
Structure

External links

Tools