SI [K10H] (P04400) Protein Card

General Information
Name SI [K10H]
Organism synthetic construct
Protein Type Synthetic
Parent SI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ICCNPACGPHYSC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1362.57
Monoisotopic Mass 1361.48
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδM. musculus(site 1)750nM+/-10010nM [125I]-BgtxGroebe,D.R. et al. (1997)
(site 2)320uM+/-8110nM [125I]-BgtxGroebe,D.R. et al. (1997)
T. marmorata(site 1)97nM+/-6210nM [125I]-BgtxGroebe,D.R. et al. (1997)
(site 2)2.0uM+/-0.3 10nM [125I]-BgtxGroebe,D.R. et al. (1997)

References
Groebe,D.R., Gray,W.R., and Abramson,S.N. (1997) Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors Biochemistry 36:6469-6474

Internal links
Nucleic acids
Structure

External links

Tools