SI [K10N] (P04401) Protein Card

General Information
Name SI [K10N]
Organism synthetic construct
Protein Type Synthetic
Parent SI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ICCNPACGPNYSC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1339.53
Monoisotopic Mass 1338.46
Isoelectric Point 7.00
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδM. musculus(site 2)420uM+/-89 10nM [125I]-BgtxGroebe,D.R. et al. (1997)
(site 1)2.1uM+/-1 10nM [125I]-BgtxGroebe,D.R. et al. (1997)
T. marmorata(site 2)5.3uM+/-0.9 10nM [125I]-BgtxGroebe,D.R. et al. (1997)
(site 1)520nM+/-100 10nM [125I]-BgtxGroebe,D.R. et al. (1997)

References
Groebe,D.R., Gray,W.R., and Abramson,S.N. (1997) Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors Biochemistry 36:6469-6474

Internal links
Nucleic acids
Structure

External links

Tools