ImI [R7E] (P04411) Protein Card

General Information
Name ImI [R7E]
Organism synthetic construct
Protein Type Synthetic
Parent ImI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPECAWRC(nh2)
Modified residues
positionsymbolname
13nh2C-term amidation
Average Mass 1324.48
Monoisotopic Mass 1323.42
Isoelectric Point 4.50
Extinction Coefficient [280nm] 5500.00

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
α7-5HT3 chimaeraH. sapiens1.6mM+/-0.13.75nM 125 I-BgtxQuiram,P.A. and Sine,S.M. (1998)

References
Quiram,P.A. and Sine,S.M. (1998) Structural elements in alpha-conotoxin ImI essential for binding to neuronal alpha7 receptors. J. Biol. Chem. 273:11007-11011

Internal links
Nucleic acids
Structure

External links

Tools