ImI [A9S] (P04412) Protein Card

General Information
Name ImI [A9S]
Organism synthetic construct
Protein Type Synthetic
Parent ImI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPRCAWRC(nh2)
Modified residues
positionsymbolname
13nh2C-term amidation
Average Mass 1351.55
Monoisotopic Mass 1350.48
Isoelectric Point 10.99
Extinction Coefficient [280nm] 5500.00

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
α7-5HT3 chimaeraH. sapiens1.9uM+/-0.23.75nM 125 I-BgtxQuiram,P.A. and Sine,S.M. (1998)

References
Quiram,P.A. and Sine,S.M. (1998) Structural elements in alpha-conotoxin ImI essential for binding to neuronal alpha7 receptors. J. Biol. Chem. 273:11007-11011

Internal links
Nucleic acids
Structure

External links

Tools