OIVA [H10P] (P04446) Protein Card

General Information
Name OIVA [H10P]
Organism synthetic construct
Protein Type Synthetic
Parent OIVA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework IV
Pharmacological family alpha conotoxin

Sequence
CCGVONAACPOCVCKNTC(nh2)
Modified residues
positionsymbolname
5O4-Hydroxyproline
11O4-Hydroxyproline
19nh2C-term amidation
Average Mass 1808.11
Monoisotopic Mass 1806.64
Isoelectric Point 10.95
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus~190uM+/-1101-10 uM AchTeichert,R.W. et al. (2006)
α1β1γδM. musculus~50nM+/-251-10 uM AchTeichert,R.W. et al. (2006)

References
Teichert,R.W., Lopez-Vera,E., Gulyas,J., Watkins,M., Rivier,J. and Olivera,B.M. (2006) Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor Biochemistry 45:1304-1312

Internal links
Nucleic acids
Structure

External links

Tools