PIIIE [R12O,Y13F] (P04449) Protein Card

General Information
Name PIIIE [R12O,Y13F]
Alternative name(s) EFE-PIIIE
Organism synthetic construct
Protein Type Synthetic
Parent PIIIE

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family alpha conotoxin

Sequence
HOOCCLYGKCROFOGCSSASCCQR(nh2)
Modified residues
positionsymbolname
2O4-Hydroxyproline
3O4-Hydroxyproline
12O4-Hydroxyproline
14O4-Hydroxyproline
25nh2C-term amidation
Average Mass 2658.02
Monoisotopic Mass 2656.03
Isoelectric Point 11.65
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδT. marmorata370nM+/-201uM AchVan Wagoner,R.M. et al. (2003)

References
Van Wagoner,R.M., Jacobsen,R.B., Olivera,B.M. and Ireland,C.M. (2003) Characterization and three-dimensional structure determination of psi-conotoxin Piiif, a novel noncompetitive antagonist of nicotinic acetylcholine receptors Biochemistry 42:6353-6362

Internal links
Nucleic acids
Structure

External links

Tools