PIIIF [Y17S,N18S,L20S] (P04453) Protein Card

General Information
Name PIIIF [Y17S,N18S,L20S]
Alternative name(s) FFE-PIIIF
Organism synthetic construct
Protein Type Synthetic
Parent PIIIF

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family alpha conotoxin

Sequence
GOOCCLYGSCROFOGCSSASCCRK(nh2)
Modified residues
positionsymbolname
2O4-Hydroxyproline
3O4-Hydroxyproline
12O4-Hydroxyproline
14O4-Hydroxyproline
25nh2C-term amidation
Average Mass 2536.88
Monoisotopic Mass 2534.97
Isoelectric Point 11.65
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδT. marmorata33nM+/-21uM AchVan Wagoner,R.M. et al. (2003)

References
Van Wagoner,R.M., Jacobsen,R.B., Olivera,B.M. and Ireland,C.M. (2003) Characterization and three-dimensional structure determination of psi-conotoxin Piiif, a novel noncompetitive antagonist of nicotinic acetylcholine receptors Biochemistry 42:6353-6362

Internal links
Nucleic acids
Structure

External links

Tools