Vc1.1 [P6O] (P04466) Protein Card

General Information
Name Vc1.1 [P6O]
Organism synthetic construct
Protein Type Synthetic
Parent Vc1.1

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDORCNYDHPEIC(nh2)
Modified residues
positionsymbolname
6O4-Hydroxyproline
17nh2C-term amidation
Average Mass 1822.97
Monoisotopic Mass 1821.63
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α9α10R. norvegicus99.1nM+/-29.70.730uM AchNevin,S.T. et al. (2007)

References
Nevin,S.T., Clark,R.J., Klimis,H., Christie,M.J., Craik,D.J. and Adams,D.J. (2007) Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins? Mol. Pharmacol. 72:1406-1410

Internal links
Nucleic acids
Structure

External links

Tools