MII [S4A,E11A,L15A] (P04477) Protein Card

General Information
Name MII [S4A,E11A,L15A]
Organism synthetic construct
Protein Type Synthetic
Parent MII

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCANPVCHLAHSNAC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1594.81
Monoisotopic Mass 1593.60
Isoelectric Point 8.42
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α2β2R. norvegicus>10uM100uM AchAzam,L. et al. (2008)
α2β4R. norvegicus>10uM100uM AchAzam,L. et al. (2008)
α3β2R. norvegicus100nM0.8100uM AchAzam,L. et al. (2008)
α3β4R. norvegicus380nM1.1100uM AchAzam,L. et al. (2008)
α4β2R. norvegicus>10uM100uM AchAzam,L. et al. (2008)
α4β4R. norvegicus>10uM100uM AchAzam,L. et al. (2008)
α6/α3β2β3R. norvegicus1.2nM1.1100uM AchAzam,L. et al. (2008)
α7R. norvegicus>10uM100uM AchAzam,L. et al. (2008)
α9α10R. norvegicus>10uM100uM AchAzam,L. et al. (2008)

References
Azam,L., Yoshikami,D., and McIntosh,J.M. (2008) Amino acid residues that confer high selectivity of the alpha6 nicotinic acetylcholine receptor subunit to alpha-conotoxin MII[S4A,E11A,L15A]. J. Biol. Chem. 283:11625-11632

Internal links
Nucleic acids
Structure

External links

Tools