KIIIA [W8L] (P04487) Protein Card

General Information
Name KIIIA [W8L]
Organism synthetic construct
Protein Type Synthetic
Parent KIIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
CCNCSSKLCRDHSRCC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1811.08
Monoisotopic Mass 1809.64
Isoelectric Point 11.73
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationRef
Nav1.2R. norvegicus31+/-71uMZhang,M.M. et al. (2007)
Nav1.4R. norvegicus15+/-41uMZhang,M.M. et al. (2007)

References
Zhang,M.M., Fiedler,B., Green,B.R., Catlin,P., Watkins,M., Garrett,J.E., Smith,B.J., Yoshikami,D., Olivera,B.M. and Bulaj,G. (2006) Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels Biochemistry 45:3723-3732

Internal links
Nucleic acids
Structure

External links

Tools