KIIIA [R10A] (P04489) Protein Card

General Information
Name KIIIA [R10A]
Organism synthetic construct
Protein Type Synthetic
Parent KIIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
CCNCSSKWCADHSRCC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1799.02
Monoisotopic Mass 1797.57
Isoelectric Point 10.92
Extinction Coefficient [280nm] 5500.00

Activity

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationRef
Nav1.2R. norvegicus45+/-51uMZhang,M.M. et al. (2007)
Nav1.4R. norvegicus42+/-31uMZhang,M.M. et al. (2007)

References
Zhang,M.M., Green,B.R., Catlin,P., Fiedler,B., Azam,L., Chadwick,A., Terlau,H., McArthur,J.R., French,R.J., Gulyas,J., Rivier,J.E., Smith,B.J., Norton,R.S., Olivera,B.M., Yoshikami,D. and Bulaj,G. (2007) Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J. Biol. Chem. 282:30699-30706

Internal links
Nucleic acids
Structure

External links

Tools