MrIA amidated (P04492) Protein Card

General Information
Name MrIA amidated
Organism synthetic construct
Protein Type Synthetic
Parent MrIA
Notes Target the noradrenaline transporter (NET) with an IC50 of 615nM (Sharpe et al. 2001).

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family chi conotoxin

Sequence
NGVCCGYKLCHPC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1391.65
Monoisotopic Mass 1390.54
Isoelectric Point 9.95
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Monoamine transporter

TargetOrganismIC50CompetitorRef
NETH. sapiens(IC50 calculated from reported pIC50. )1.7 uM[3H]nisoxetine 4.3 nMBrust,A. et al. (2009)

References
Sharpe,I.A., Gehrmann,J., Loughnan,M.L., Thomas,L., Adams,D.A., Atkins,A., Palant,E., Craik,D.J., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2001) Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter Nat. Neurosci. 4:902-907
Brust,A., Palant,E., Croker,D.E., Colless,B., Drinkwater,R., Patterson,B., Schroeder,C.I., Wilson,D., Nielsen,C.K., Smith,M.T., Alewood,D., Alewood,P.F. and Lewis,R.J. (2009) chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. 52:6991-7002

Internal links
Nucleic acids
Structure

External links

Tools