Mr1.8 (P04662) Protein Card

General Information
Name Mr1.8
Alternative name(s) Mr002,Mr1.7,Mr1.7b
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Mr1.8 precursor (4571)
Notes The modification of two prolines into 4-hydroxyprolines were detected by MS but the assignment of which of the three prolines was modified is uncertain.

Jin et al. 2014 called this peptide with the name Mr1.7 but it was published with the name Mr1.8 by Liu et al 2012. Liu et al 2012 also published a peptide precursor Mr1.7 which is related but not identical to Mr1.8.


Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family

Sequence
ROECCTHOACHVSNPELCS
Modified residues
positionsymbolname
2O4-Hydroxyproline
8O4-Hydroxyproline
Sequence evidence protein level
Average Mass 2111.32
Monoisotopic Mass 2109.81
Isoelectric Point 6.81
Extinction Coefficient [280nm] -1.00

References
Liu,Z., Li,H., Liu,N., Wu,C., Jiang,J., Yue,J. and Dai,Q. (2012) Diversity and evolution of conotoxins in Conus virgo, Conus eburneus, Conus imperialis and Conus marmoreus from the South China Sea. Toxicon 60:982-989
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J. (2013) Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics 12:312-329
Jin,A.H., Vetter,I., Dutertre,S., Abraham,N., Emidio,N.B., Inserra,M., Murali,S.S., Christie,M.J., Alewood,P.F. and Lewis,R.J. (2014) MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors. Biochemistry 53:1-3

Internal links
Protein Precursor Mr1.8 precursor (4571)
Nucleic acids
Structure

External links

Tools