VcIA precursor (P00499) Protein Card

General Information
Name VcIA precursor
Organism Conus victoriae
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Pharmacological family

Sequence
MGMRMMFTVFLLVVLATTVVSSTSG
RREFRGRNAAAKASDL
VSLTDKKR
GCCSDPRCNYDHPEIC
G
Sequence region
[1-25]signal sequence
[50-65]mature peptideVcIA

References
Clark,R.J., Fischer,H., Nevin,S.T., Adams,D.J. and Craik,D.J. (2006) The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1 J. Biol. Chem. 281:23254-23263
Sandall,D.W., Satkunanathan,N., Keays,D.A., Polidano,M.A., Liping,X., Pham,V., Down,J.G., Khalil,Z., Livett,B.G. and Gayler,K.R. (2003) A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo Biochemistry 42:6904-6911
Jakubowski,J.A., Keays,D.A., Kelley,W.P., Sandall,D.W., Bingham,J.P., Livett,B.G., Gayler,K.R. and Sweedler,J.V. (2004) Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry J Mass Spectrom 39:548-557
Lang,P.M., Burgstahler,R., Haberberger,R.V., Sippel,W. and Grafe,P. (2005) A conus peptide blocks nicotinic receptors of unmyelinated axons in human nerves Neuroreport 16:479-483
Satkunanathan,N., Livett,B., Gayler,K., Sandall,D., Down,J. and Khalil,Z. (2005) Alpha-conotoxin Vc1.1 alleviates neuropathic pain and accelerates functional recovery of injured neurones Brain Res. 1059:149-158

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P69747
Ncbi P69747

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