GeXIVA precursor (P05224) Protein Card

General Information
Name GeXIVA precursor
Alternative name(s) CTX-GeXIVAWT,Ge14.1
Organism Conus generalis
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework XIV
Pharmacological family

Sequence
MKLTCVLIITVLFLTACQLTTA
VTYSRGEHKHRALMSTGTN
YRLPK
TCRSSGRYCRSPYDCRRRYCRRITDACV
Sequence region
[1-22]signal sequence
[47-74]mature peptideGeXIVA[bead]
[47-74]mature peptideGeXIVA[globular]
[47-74]mature peptideGeXIVA[ribbon]

References
Luo,S., Zhangsun,D., Harvey,P.J., Kaas,Q., Wu,Y., Zhu,X., Hu,Y., Li,X., Tsetlin,V.I., Christensen,S., Romero,H.K., McIntyre,M., Dowell,C., Baxter,J.C., Elmslie,K.S., Craik,D.J. and McIntosh,J.M. (2015) Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. Proc. Natl. Acad. Sci. U.S.A. 112-35

Internal links
Nucleic acids GeXIVAWT precursor, mRNA, complete cds
Structure

External links
Ncbi AFP87476, J7GY56

Tools