Y-Pl1 (P05239) Protein Card

General Information
Name Y-Pl1
Alternative name(s) CPY-Pl1
Organism Conus planorbis
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Y-Pl1 precursor (5238)

Classification
Conopeptide class conopeptide Y
Gene superfamily
Pharmacological family kappa conotoxin

Sequence
ARFLHPFQYYTLYRYLTRFLHRYPIYYIRY
Sequence evidence protein level
Average Mass 4094.80
Monoisotopic Mass 4092.14
Isoelectric Point 13.10
Extinction Coefficient [280nm] 11920.00

Activity

IC50: Voltage-Gated Potassium Channels

TargetOrganismIC50Ref
Kv1.6H. sapiens170nMImperial,J.S. et al. (2008)

References
Imperial,J.S., Chen,P., Sporning,A., Terlau,H., Daly,N.L., Craik,D.J. and Olivera,B.M. (2008) Tyrosine-rich conopeptides affect voltage-gated K+ channels. J. Biol. Chem. 283:23026-23032

Internal links
Protein Precursor Y-Pl1 precursor (5238)
Nucleic acids
Structure

External links

Tools