CnVA (P05354) Protein Card

General Information
Name CnVA
Organism Conus consors
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Notes No activity detected at 5-10 uM on 30 different class A GPCRs, ion channels (NaV1.2, 1.3, 1.4, 1.5, 1.6, 1.8 and insect BgNaV1; KV1.1, 1.2, 1.3, 1.4, 1.5, 1.6, KV2.1, hERG and insect channel Shaker IR), muscular and neuronal nicotinic receptors (four subtypes) and neurotransmitter transporters (three subfamilies) [Petrel 2013].

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework V
Pharmacological family tau conotoxin

Sequence
ECCHRQLLCCLRFV(nh2)
Modified residues
positionsymbolname
15nh2C-term amidation
Sequence evidence protein level
Average Mass 1718.10
Monoisotopic Mass 1716.78
Isoelectric Point 10.94
Extinction Coefficient [280nm] 500.00

Activity

Ki: Somatostatin receptors

TargetOrganismKiCompetitorAgonistRef
sst1H. sapiens169 uM+/-35125I-[Tyr11]-somatostatin (0.05 nM)Petrel,C. et al. (2013)
sst2H. sapiens159uM+/-38125I-[Tyr11]-somatostatin (0.05nM)Petrel,C. et al. (2013)
sst3H. sapiens1.50uM+/-0.16125I-[Tyr11]-somatostatin (0.05nM)Petrel,C. et al. (2013)
sst4H. sapiens> 100uM125I-[Tyr11]-somatostatin (0.05nM)Petrel,C. et al. (2013)
sst5H. sapiens80.2uM+/-11.5125I-[Tyr11]-somatostatin (0.05nM)Petrel,C. et al. (2013)

References
Petrel,C., Hocking,H.G., Reynaud,M., Upert,G., Favreau,P., Biass,D., Paolini-Bertrand,M., Peigneur,S., Tytgat,J., Gilles,N., Hartley,O., Boelens,R., Stocklin,R. and Servent,D. (2013) Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor. Biochem. Pharmacol.

Internal links
Nucleic acids
Structure SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU- CONOTOXIN CnVA

External links
Ncbi 3ZKT_A, P0DJL6

Tools