BuIIIB[V1A] (P05360) Protein Card

General Information
Name BuIIIB[V1A]
Organism synthetic construct
Protein Type Synthetic
Parent BuIIIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
AGERCCKNGKRGCGRWCRDHSRCC(nh2)
Modified residues
positionsymbolname
25nh2C-term amidation
Average Mass 2735.12
Monoisotopic Mass 2733.13
Isoelectric Point 12.36
Extinction Coefficient [280nm] 5500.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.3R. norvegicus710nM+/-30Kuang,Z. et al. (2013)

References
Kuang,Z., Zhang,M.M., Gupta,K., Gajewiak,J., Gulyas,J., Balaram,P., Rivier,J.E., Olivera,B.M., Yoshikami,D., Bulaj,G. and Norton,R.S. (2013) Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency. ACS Chem. Biol. 8:1344-1351

Internal links
Nucleic acids
Structure

External links

Tools