As25a (P05524) Protein Card

General Information
Name As25a
Alternative name(s) As25b
Organism Conus austini
Organism region Western Atlantic and Caribbean
Organism diet vermivorous
Protein Type Wild type
Notes In Aguilar 2013, As25b is described as the peptide modified with two 4-hydroxyproline whereas As25a is the same peptide but without modification. Because it is now well established that the differential modifications of conopeptides is a common mechanism to increase diversity and occurs for nearly every peptide, ConoServer now record only the conopeptide sequences with the maximal number of modifications. Therefore, the peptides called As25a and As25b in Aguilar 2013 are considered as only one entry, called As25a in ConoServer.

Intracranial injection in mice of the peptide without the two 4-hydroxyprolines provokes paralysis of the hind limbs and death.


Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework XXV
Pharmacological family

Sequence
CKCOSCNFNDVTENCKCCIFRQO(nh2)
Modified residues
positionsymbolname
4O4-Hydroxyproline
23O4-Hydroxyproline
24nh2C-term amidation
Sequence evidence protein level
Average Mass 2678.05
Monoisotopic Mass 2676.05
Isoelectric Point 10.68
Extinction Coefficient [280nm] 750.00

References
Aguilar,M.B., Zugasti-Cruz,A., Falcón,A., Batista,C.V., Olivera,B.M. and Heimer de la Cotera,E.P. (2013) A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico. Peptides [ahead of print]

Internal links
Nucleic acids
Structure

External links
Ncbi P0DM45

Tools