TxIB(G) (P05528) Protein Card

General Information
Name TxIB(G)
Organism synthetic construct
Protein Type Synthetic
Parent TxIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSDPPCRNKHPDLCG
Average Mass 1798.01
Monoisotopic Mass 1796.68
Isoelectric Point 8.31
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus>10uM10uM AChLuo,S. et al. (2013)
α2β2R. norvegicus>10uM100uM AChLuo,S. et al. (2013)
α2β4R. norvegicus>10uM100uM AChLuo,S. et al. (2013)
α3β2R. norvegicus>10uM100uM AChLuo,S. et al. (2013)
α3β4R. norvegicus>10uM100uM AChLuo,S. et al. (2013)
α4β2R. norvegicus>10uM100uM AChLuo,S. et al. (2013)
α4β4R. norvegicus>10uM100uM AChLuo,S. et al. (2013)
α6/α3β2β3R. norvegicus247nM+/-82100uM AChLuo,S. et al. (2013)
α6/α3β4R. norvegicus>10uM100uM AChLuo,S. et al. (2013)
α7R. norvegicus>10uM200uM AChLuo,S. et al. (2013)
α9α10R. norvegicus>10uM10uM AChLuo,S. et al. (2013)

References
Luo,S., Zhangsun,D., Wu,Y., Zhu,X., Hu,Y., McIntyre,M., Christensen,S., Akcan,M., Craik,D.J. and McIntosh,J.M. (2013) Characterization of a novel α-conotoxin from conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors. J. Biol. Chem. 288:894-902

Internal links
Nucleic acids
Structure

External links

Tools