Conantokin-G[Gla10Buc,Gla14Buc] (P05697) Protein Card

General Information
Name Conantokin-G[Gla10Buc,Gla14Buc]
Organism synthetic construct
Protein Type Synthetic
Parent Conantokin-G

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GE(Gla)(Gla)LQ(Gla)NQ(Buc)LIR(Buc)KSN(nh2)
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
7GlaGamma carboxylic glutamic acid
10BucCarbabridge [C4 unsaturated] (half)
14BucCarbabridge [C4 unsaturated] (half)
18nh2C-term amidation
Average Mass 2116.23
Monoisotopic Mass 2115.01
Isoelectric Point 2.50
Extinction Coefficient [280nm] NA

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50AgonistRef
GluN2AR. norvegicus>10uM200uM glutamatePlatt,R.J. et al. (2012)
GluN2BR. norvegicus0.15uM200uM glutamatePlatt,R.J. et al. (2012)
GluN2CR. norvegicus~10uM 200uM glutamatePlatt,R.J. et al. (2012)
GluN2DR. norvegicus0.75uM 200uM glutamatePlatt,R.J. et al. (2012)

References
Platt,R.J., Han,T.S., Green,B.R., Smith,M.D., Skalicky,J., Gruszczynski,P., White,H.S., Olivera,B., Bulaj,G. and Gajewiak,J. (2012) Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. J. Biol. Chem. 287:20727-20736

Internal links
Nucleic acids
Structure

External links

Tools