Conantokin-G[Gla10Bsc,Gla14Bsc] (P05698) Protein Card

General Information
Name Conantokin-G[Gla10Bsc,Gla14Bsc]
Organism synthetic construct
Protein Type Synthetic
Parent Conantokin-G

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GE(Gla)(Gla)LQ(Gla)NQ(Bsc)LIR(Bsc)KSN(nh2)
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
7GlaGamma carboxylic glutamic acid
10BscCarbabridge [C4 saturated] (half)
14BscCarbabridge [C4 saturated] (half)
18nh2C-term amidation
Average Mass 2118.24
Monoisotopic Mass 2117.02
Isoelectric Point 2.50
Extinction Coefficient [280nm] NA

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50AgonistRef
GluN2AR. norvegicus>10uM200uM glutamatePlatt,R.J. et al. (2012)
GluN2BR. norvegicus0.64uM200uM glutamatePlatt,R.J. et al. (2012)
GluN2CR. norvegicus>10uM 200uM glutamatePlatt,R.J. et al. (2012)
GluN2DR. norvegicus>10uM200uM glutamatePlatt,R.J. et al. (2012)

References
Platt,R.J., Han,T.S., Green,B.R., Smith,M.D., Skalicky,J., Gruszczynski,P., White,H.S., Olivera,B., Bulaj,G. and Gajewiak,J. (2012) Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. J. Biol. Chem. 287:20727-20736

Internal links
Nucleic acids
Structure

External links

Tools