Conantokin-G[+10Gla,Gla10Buc,Gla14Buc] (P05699) Protein Card

General Information
Name Conantokin-G[+10Gla,Gla10Buc,Gla14Buc]
Organism synthetic construct
Protein Type Synthetic
Parent Conantokin-G

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GE(Gla)(Gla)LQ(Gla)NQ(Gla)(Buc)LIR(Buc)KS
N(nh2)
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
7GlaGamma carboxylic glutamic acid
10GlaGamma carboxylic glutamic acid
11BucCarbabridge [C4 unsaturated] (half)
15BucCarbabridge [C4 unsaturated] (half)
19nh2C-term amidation
Average Mass 2289.35
Monoisotopic Mass 2288.04
Isoelectric Point 2.20
Extinction Coefficient [280nm] NA

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50AgonistRef
GluN2AR. norvegicus>10uM200uM glutamatePlatt,R.J. et al. (2012)
GluN2BR. norvegicus0.7uM200uM glutamatePlatt,R.J. et al. (2012)
GluN2CR. norvegicus>10uM200uM glutamatePlatt,R.J. et al. (2012)
GluN2DR. norvegicus>10uM200uM glutamatePlatt,R.J. et al. (2012)

References
Platt,R.J., Han,T.S., Green,B.R., Smith,M.D., Skalicky,J., Gruszczynski,P., White,H.S., Olivera,B., Bulaj,G. and Gajewiak,J. (2012) Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. J. Biol. Chem. 287:20727-20736

Internal links
Nucleic acids
Structure

External links

Tools