SIIIA[del1] (P05812) Protein Card

General Information
Name SIIIA[del1] (named by ConoServer)
Alternative name(s) SIIIA(2-20)
Organism synthetic construct
Protein Type Synthetic
Parent SIIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
NCCNGGCSSKWCRDHARCC(nh2)
Modified residues
positionsymbolname
20nh2C-term amidation
Average Mass 2096.34
Monoisotopic Mass 2094.72
Isoelectric Point 11.62
Extinction Coefficient [280nm] 5500.00

Activity

Ki: Voltage-Gated Sodium Channels

TargetOrganismKiCompetitorAgonistRef
Nav1.2R. norvegicus(Measured in rat brain preparation.)5.39 nM125I-TIIIASchroeder,C.I. et al. (2008)
Nav1.4R. norvegicus(Measured in rat muscle preparation.)46.78 nM125I-TIIIASchroeder,C.I. et al. (2008)

References
Schroeder,C.I., Ekberg,J., Nielsen,K.J., Adams,D., Loughnan,M.L., Thomas,L., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2008) Neuronally mu-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J. Biol. Chem. 283:21621-21628
Schroeder,C.I., Adams,D., Thomas,L., Alewood,P.F. and Lewis,R.J. (2012) N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers 98:161-165

Internal links
Nucleic acids
Structure

External links

Tools