MIC (P05865) Protein Card

General Information
Name MIC
Organism Conus magus (Magus cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Parent MI
Notes Truncated form of MI

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
CCHPACGKNYSC(nh2)
Modified residues
positionsymbolname
13nh2C-term amidation
Sequence evidence protein level
Average Mass 1280.47
Monoisotopic Mass 1279.43
Isoelectric Point 10.95
Extinction Coefficient [280nm] 1490.00

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
α1β1γδT. californica248.7nM+/-10.92nM [3H]epibatidineKapono,C.A. et al. (2013)
α3β4*S. scrofa>5uM0.5 nM [3H]epibatidineKapono,C.A. et al. (2013)
α4β2*R. norvegicus>10uM0.5 nM [3H]epibatidineKapono,C.A. et al. (2013)

References
Kapono,C.A., Thapa,P., Cabalteja,C.C., Guendisch,D., Collier,A.C. and Bingham,J.P. (2013) Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus. Toxicon

Internal links
Nucleic acids
Structure

External links

Tools