BuIA[T5A] (P05868) Protein Card

General Information
Name BuIA[T5A]
Organism synthetic construct
Protein Type Synthetic
Parent BuIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSAPPCAVLYC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1281.53
Monoisotopic Mass 1280.48
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α6/α3β2β3R. norvegicus7.6nM+/-0.81100uM AchAzam,L. et al. (2010)
α6/α3β4R. norvegicus3.8nM+/-0.91.4100uM AchAzam,L. et al. (2010)

References
Azam,L., Maskos,U., Changeux,J.P., Dowell,C.D., Christensen,S., De Biasi,M. and McIntosh,J.M. (2010) α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. FASEB J. 24:5113-5123

Internal links
Nucleic acids
Structure

External links

Tools