BuIA[P7O] (P05870) Protein Card

General Information
Name BuIA[P7O]
Organism synthetic construct
Protein Type Patent
Parent BuIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSTPOCAVLYC(nh2)
Modified residues
positionsymbolname
7O4-Hydroxyproline
14nh2C-term amidation
Average Mass 1327.56
Monoisotopic Mass 1326.49
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α6/α3β2β3R. norvegicus4.1nM+/-0.50.73100uM AchAzam,L. et al. (2010)
α6/α3β4R. norvegicus7.7nM+/-6.32.1100uM AchAzam,L. et al. (2010)

References
Azam,L., Maskos,U., Changeux,J.P., Dowell,C.D., Christensen,S., De Biasi,M. and McIntosh,J.M. (2010) α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. FASEB J. 24:5113-5123

Internal links
Nucleic acids
Structure

External links

Tools