TxVIA precursor (P00598) Protein Card

General Information
Name TxVIA precursor
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Pharmacological family

Sequence
MKLTCMMIVAVLFLTAWTFATA
DDPRNGLGNLFSNAHHEMK
NPEASKLNKR
WCKQSGEMCNLLDQNCCDGYCIVLVCT
Sequence region
[1-22]signal sequence
[52-78]mature peptideTxVIA

References
Woodward,S.R., Cruz,L.J., Olivera,B.M. and Hillyard,D.R. (1990) Constant and hypervariable regions in conotoxin propeptides EMBO J. 9:1015-1020
Hillyard,D.R., Olivera,B.M., Woodward,S., Corpuz,G.P., Gray,W.R., Ramilo,C.A. and Cruz,L.J. (1989) A molluscivorous Conus toxin: conserved frameworks in conotoxins Biochemistry 28:358-361
Fainzilber,M., Gordon,D., Hasson,A., Spira,M.E. and Zlotkin,E. (1991) Mollusc-specific toxins from the venom of Conus textile neovicarius Eur. J. Biochem. 202:589-595
Hasson,A., Fainzilber,M., Gordon,D., Zlotkin,E. and Spira,M.E. (1993) Alteration of sodium currents by new peptide toxins from the venom of a molluscivorous Conus snail Eur. J. Neurosci. 5:56-64
Fainzilber,M., Kofman,O., Zlotkin,E. and Gordon,D. (1994) A new neurotoxin receptor site on sodium channels is identified by a conotoxin that affects sodium channel inactivation in molluscs and acts as an antagonist in rat brain J. Biol. Chem. 269:2574-2580
Shon,K.J., Hasson,A., Spira,M.E., Cruz,L.J., Gray,W.R. and Olivera,B.M. (1994) Delta-conotoxin GmVIA, a novel peptide from the venom of Conus gloriamaris Biochemistry 33:11420-11425
Kohno,T., Sasaki,T., Kobayashi,K., Fainzilber,M. and Sato,K. (2002) Three-dimensional solution structure of the sodium channel agonist/antagonist delta-conotoxin TxVIA J. Biol. Chem. 277:36387-36391

Internal links
Nucleic acids C.texile KK-0 mRNA for conotoxin
O-Superfamily Conotoxin Peptides.
Structure

External links
UniProtKB/Swiss-Prot P18511
Ncbi P18511, CAA37377

Tools