OmIA (P00006) Protein Card

General Information
Name OmIA
Alternative name(s) Om1a
Organism Conus omaria
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACNVNNPHICG(nh2)
Modified residues
positionsymbolname
18nh2C-term amidation
Sequence evidence protein level
Average Mass 1720.93
Monoisotopic Mass 1719.65
Isoelectric Point 8.42
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α1β1δεM. musculus>10uM10uM AchTalley,T.T. et al. (2006)
α2β2R. norvegicus>10uM100uM AchTalley,T.T. et al. (2006)
α3β2R. norvegicus11.0nM+/-6100nM AchTalley,T.T. et al. (2006)
α3β4R. norvegicus>10uM100nM AchTalley,T.T. et al. (2006)
α4β2R. norvegicus>10uM100nM AchTalley,T.T. et al. (2006)
α6/α3β2R. norvegicus201nM+/-100100nM AchTalley,T.T. et al. (2006)
α7H. sapiens290 nM[240-340]1.2200uM AchYu et al. (2018)
R. norvegicus27.1nM+/-12200uM AchTalley,T.T. et al. (2006)
59 nM[51-69]1.2200uM AchYu et al. (2018)

References
Talley,T.T., Olivera,B.M., Han,K.H., Christensen,S.B., Dowell,C., Tsigelny,I., Ho,K.Y., Taylor,P. and McIntosh,J.M. (2006) Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors J. Biol. Chem. 281:24678-24686
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H. (2006) Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes Biochem. Biophys. Res. Commun. 345:248-254
Yu, J., Zhu, X., Zhang, L., Kudryavtsev, D., Kasheverov, I., Lei, Y., Zhangsun, D., Tsetlin, V. and Luo, S. (2018) Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists Neuropharmacology 139:226-237

Internal links
Nucleic acids
Structure SOLUTION STRUCTURE OF ALPHA-CONOTOXIN OMIA

External links
UniProtKB/Swiss-Prot P0C1R7
Ncbi 2GCZ_A, P0C1R7

Tools