OmIA (P00006) Protein Card

General Information
Name OmIA
Alternative name(s) Om1a
Organism Conus omaria
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACNVNNPHICG(nh2)
Modified residues
positionsymbolname
18nh2C-term amidation
Sequence evidence protein level
Average Mass 1720.93
Monoisotopic Mass 1719.65
Isoelectric Point 8.42
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus>10uM10uM AchTalley,T.T. et al. (2006)
α2β2R. norvegicus>10uM100uM AchTalley,T.T. et al. (2006)
α3β2R. norvegicus11.0nM+/-6100nM AchTalley,T.T. et al. (2006)
α3β4R. norvegicus>10uM100nM AchTalley,T.T. et al. (2006)
α4β2R. norvegicus>10uM100nM AchTalley,T.T. et al. (2006)
α6/α3β2R. norvegicus201nM+/-100100nM AchTalley,T.T. et al. (2006)
α7R. norvegicus27.1nM+/-12200uM AchTalley,T.T. et al. (2006)

References
Talley,T.T., Olivera,B.M., Han,K.H., Christensen,S.B., Dowell,C., Tsigelny,I., Ho,K.Y., Taylor,P. and McIntosh,J.M. (2006) Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors J. Biol. Chem. 281:24678-24686
Chi,S.W., Kim,D.H., Olivera,B.M., McIntosh,J.M. and Han,K.H. (2006) Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes Biochem. Biophys. Res. Commun. 345:248-254

Internal links
Nucleic acids
Structure SOLUTION STRUCTURE OF ALPHA-CONOTOXIN OMIA

External links
UniProtKB/Swiss-Prot P0C1R7
Ncbi 2GCZ_A, P0C1R7

Tools