Mr1.8a (P06002) Protein Card

General Information
Name Mr1.8a (named by ConoServer)
Alternative name(s) Mr1.7a
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Mr1.8 precursor (4571)
Notes Jin et al. 2014 called this peptide with the name Mr1.7 but it was published with the name Mr1.8 by Liu et al 2012. Liu et al 2012 also published a peptide precursor Mr1.7 which is related but not identical to Mr1.8. The variant Mr1.7a was renamed Mr1.8a. There is also doubt that it could come from the same precursor as the C-terminal amidation could only happen from the cleavage of a glycine but the precursor of Mr1.8 has a serine. The name is therefore susceptible to change if a more likely precursor for this peptide is discovered.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family

Sequence
ECCTHPACHVSNPELC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1737.95
Monoisotopic Mass 1736.65
Isoelectric Point 5.63
Extinction Coefficient [280nm] NA

References
Jin,A.H., Vetter,I., Dutertre,S., Abraham,N., Emidio,N.B., Inserra,M., Murali,S.S., Christie,M.J., Alewood,P.F. and Lewis,R.J. (2014) MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors. Biochemistry 53:1-3

Internal links
Protein Precursor Mr1.8 precursor (4571)
Nucleic acids
Structure

External links

Tools