Vc1.1 [Cys2Agl,Cys8Agl] (P06292) Protein Card

General Information
Name Vc1.1 [Cys2Agl,Cys8Agl]
Alternative name(s) 8]-cis dicarba Vc1.1,[2
Organism synthetic construct
Protein Type Synthetic
Parent Vc1.1

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
G(Agl)CSDPR(Agl)NYDHPEIC(nh2)
Modified residues
positionsymbolname
2AglCarbabridge [C2 unsaturated] (half)
8AglCarbabridge [C2 unsaturated] (half)
17nh2C-term amidation
Average Mass 1772.92
Monoisotopic Mass 1771.74
Isoelectric Point 5.63
Extinction Coefficient [280nm] 1490.00

References
van Lierop,B.J., Robinson,S.D., Kompella,S.N., Belgi,A., McArthur,J.R., Hung,A., MacRaild,C.A., Adams,D.J. and Robinson,A.J. (2013) Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. ACS Chem. Biol. 8:1815-1821

Internal links
Nucleic acids
Structure Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-cis dicarba Vc1.1
Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-trans dicarba Vc1.1

External links
Ncbi 2MFX_A, 2MFY_A

Tools