Conorphin-T precursor (P00646) Protein Card

General Information
Name Conorphin-T precursor (named by ConoServer)
Alternative name(s) TxMRCL-03 precursor
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Precursor
Notes This precusor was previously named in ConoServer "TeAr193 precursor" because the predicted mature peptide was TeAr193, but it was subsequently discovered at the protein level that TeAr193 has a different sequence, corresponding to a different processing (Bhatia 2012). Therefore the name of this precursor P00646 was reverted to TxMRCL-03.Brust et al, 2016 reported conorphin-T which have the same sequence as TxMRCL-03 but shorter.

Classification
Conopeptide class conotoxin
Gene superfamily T superfamily
Pharmacological family

Sequence
MRCLPVFVILLLLIASAPSVDA
QPKTKDDIPQASFLDNAKR
YLQVLESKR
NCCRRQICC
GRPS
Sequence region
[1-22]signal sequence
[51-59]mature peptideConorphin-T[globular]
[51-59]mature peptideConorphin-T[bead]
[51-59]mature peptideConorphin-T[ribbon]

References
Conticello,S.G., Gilad,Y., Avidan,N., Ben-Asher,E., Levy,Z. and Fainzilber,M. (2001) Mechanisms for evolving hypervariability: the case of conopeptides Mol. Biol. Evol. 18:120-131
Brust A., Croker D. E., Colless B., Ragnarsson L., Andersson A., Jain K., Garcia-Caraballo S., Castro J., Brierley S. M., Alewood P. F., Lewis R. J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J. Med. Chem.

Internal links
Nucleic acids Conus textile clone TxMRCL-03 conotoxin scaffold IX precursor, mRNA, complete cds
Structure

External links
UniProtKB/Swiss-Prot Q9BPG9
Ncbi AAG60387

Tools