contryphan-Vc2 (P06614) Protein Card

General Information
Name contryphan-Vc2
Organism Conus victoriae
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor contryphan-Vc2 precursor (6334)
Notes The D-Trp PTM was assumed by similarity. The L-Trp variant had similar activity by injection in mice (Drane 2017).

Classification
Conopeptide class contryphan
Gene superfamily O2 superfamily
Pharmacological family

Sequence
CRwTPVC
Modified residues
positionsymbolname
3wD-tryptophan
Sequence evidence nucleic acid level
Average Mass 862.03
Monoisotopic Mass 861.36
Isoelectric Point 11.65
Extinction Coefficient [280nm] 5500.00

Synthetic variants
contryphan-Vc2 [L-Trp3]CVPTWRC

References
Robinson,S.D., Safavi-Hemami,H., McIntosh,L.D., Purcell,A.W., Norton,R.S. and Papenfuss,A.T. (2014) Diversity of Conotoxin Gene Superfamilies in the Venomous Snail, Conus victoriae. PLoS ONE 9
Drane,S.B., Robinson,S.D., MacRaild,C.A., Chhabra,S., Chittoor,B., Morales,R.A., Leung,E.W., Belgi,A., Espino,S.S., Olivera,B.M., Robinson,A.J., Chalmers,D.K. and Norton,R.S. (2017) Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue. Toxicon 129:113-122

Internal links
Protein Precursor contryphan-Vc2 precursor (6334)
Nucleic acids
Structure Calculated solution structure of [D-Trp3]-Contryphan-Vc2

External links

Tools