AusIA (P06679) Protein Card

General Information
Name AusIA
Organism Conus australis
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
SCCARNPACRHNHPCV
Average Mass 1764.00
Monoisotopic Mass 1762.70
Isoelectric Point 12.50
Extinction Coefficient [280nm] -1.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α7G. gallus(globular)11.68 uM+/-1.53200 uM AchLebbe,E.K. et al. (2014)
(ribbon)9.67 uM+/-0.01200 uM AchLebbe,E.K. et al. (2014)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α1β1δεR. norvegicus(globular)010 uM AchLebbe,E.K. et al. (2014)
(ribbon)0 10 uM AchLebbe,E.K. et al. (2014)
α1β1γδR. norvegicus(globular)010 uM AchLebbe,E.K. et al. (2014)
(ribbon)0 10 uM AchLebbe,E.K. et al. (2014)
α3β4H. sapiens(ribbon)070 uM AchLebbe,E.K. et al. (2014)
(globular)070 uM AchLebbe,E.K. et al. (2014)
α4β2H. sapiens(ribbon)050 uM AchLebbe,E.K. et al. (2014)
(globular)050 uM AchLebbe,E.K. et al. (2014)
α4β4H. sapiens(ribbon)050 uM AchLebbe,E.K. et al. (2014)
(globular)050 uM AchLebbe,E.K. et al. (2014)
α7G. gallus(globular)40200 uM AchLebbe,E.K. et al. (2014)
(ribbon)51200 uM AchLebbe,E.K. et al. (2014)

References
Lebbe,E.K., Peigneur,S., Maiti,M., Mille,B.G., Devi,P., Ravichandran,S., Lescrinier,E., Waelkens,E., D'Souza,L. and Tytgat,J. (2014) Discovery of a new subclass of α-conotoxins in the venom of Conus australis. Toxicon 91:145-154

Internal links
Nucleic acids
Structure

External links
Ncbi P0DL39

Tools