PeIA[A7V] (P06793) Protein Card

General Information
Name PeIA[A7V]
Organism synthetic construct
Protein Type Synthetic
Parent PeIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPVCSVNHPELC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence Unknown
Average Mass 1679.91
Monoisotopic Mass 1678.65
Isoelectric Point 6.81
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus85.6 nM+/-19100 uM AchHone,A.J. et al. (2013)
α6/α3β2β3R. norvegicus6.9 nM+/-0.4100 uM AchHone,A.J. et al. (2013)

References
Hone,A.J., Ruiz,M., Scadden,M., Christensen,S., Gajewiak,J., Azam,L. and McIntosh,J.M. (2013) Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors. J. Biol. Chem. 288:25428-25439

Internal links
Nucleic acids
Structure

External links

Tools