Conorfamide-Vc1 (P06810) Protein Card

General Information
Name Conorfamide-Vc1
Alternative name(s) CNF-Vc1
Organism Conus victoriae
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor conorfamide-Vc1 precursor (6812)
Notes Sequence from MS/MS data matched against transcriptomic data. Potentially a new superfamily. Espino et al.2018 reported that Conorfamide-Vc1 against mouse MRGPRC11 at 10 µM is inactive.

Classification
Conopeptide class conorfamide
Gene superfamily
Pharmacological family

Sequence
HSGFLLAWSGPRNRFVRF(nh2)
Modified residues
positionsymbolname
19nh2C-term amidation
Sequence evidence protein level
Average Mass 2146.50
Monoisotopic Mass 2145.15
Isoelectric Point 12.80
Extinction Coefficient [280nm] 5500.00

Activity

EC50: Class A Orphans

TargetOrganismEC50Ref
MRGPRX1H. sapiens1.8 μMEspino et al. (2018)

Synthetic variants
Conorfamide-Vc1 [del1-14]FVRF(nh2)
Conorfamide-Vc1 [del1-6]AWSGPRNRFVRF(nh2)

References
Robinson,S.D., Safavi-Hemami,H., Raghuraman,S., Imperial,J.S., Papenfuss,A.T., Teichert,R.W., Purcell,A.W., Olivera,B.M. and Norton,R.S. (2015) Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom. J Proteomics 114:38-47
Espino, S.S., Robinson, S.D., Safavi-Hemami, H., Gajewiak, J., Yang, W., Olivera, B.M. and Liu, Q. (2018) Conopeptides promote itch through human itch receptor hMgprX1 Toxicon 154:28-34

Internal links
Protein Precursor conorfamide-Vc1 precursor (6812)
Nucleic acids
Structure

External links

Tools